Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CLDN5, OCLN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CLDN5, OCLN |
| Key Genes/Proteins | OCLN, STROKE, ACTB, CLDN5, GAPDH, SDHA |
| Related Diseases | Stroke, neurodegeneration |
Knowledge base pages for this entity
graph TD
CLDN5__OCLN["CLDN5, OCLN"]
CLDN5__OCLN -->|"activates"| Stroke["Stroke"]
CLDN5__OCLN -->|"activates"| STROKE["STROKE"]
CLDN5__OCLN -->|"activates"| OCLN["OCLN"]
CLDN5__OCLN -->|"expressed in"| Cortex["Cortex"]
CLDN5__OCLN -->|"debate_co_mention"| FCGRT["FCGRT"]
CLDN5__OCLN -->|"debate_co_mention"| LRP1["LRP1"]
CLDN5__OCLN -->|"debate_co_mention"| LRP1__MTNR1A__MTNR1B["LRP1, MTNR1A, MTNR1B"]
CLDN5__OCLN -->|"debate_co_mention"| MTNR1A["MTNR1A"]
GENES["GENES"] -->|"regulates"| CLDN5__OCLN
ACTB["ACTB"] -->|"regulates"| CLDN5__OCLN
CLDN5["CLDN5"] -->|"activates"| CLDN5__OCLN
GAPDH["GAPDH"] -->|"regulates"| CLDN5__OCLN
SDHA["SDHA"] -->|"regulates"| CLDN5__OCLN
UBC["UBC"] -->|"regulates"| CLDN5__OCLN
AND["AND"] -->|"activates"| CLDN5__OCLN
ZO1["ZO1"] -->|"activates"| CLDN5__OCLN| Target | Relation | Type | Str |
|---|---|---|---|
| Stroke | activates | disease | 0.65 |
| OCLN | activates | gene | 0.60 |
| STROKE | activates | gene | 0.60 |
| Cortex | expressed_in | brain_region | 0.55 |
| neurodegeneration | associated_with | disease | 0.50 |
| FCGRT | debate_co_mention | gene | 0.45 |
| LRP1 | debate_co_mention | gene | 0.45 |
| LRP1, MTNR1A, MTNR1B | debate_co_mention | gene | 0.45 |
| MTNR1A | debate_co_mention | gene | 0.45 |
| LRP1, MTNR1A, MTNR1B | co_associated_with | gene | 0.40 |
| TFR1, LRP1, CAV1, ABCB1 | co_associated_with | gene | 0.40 |
| TFR1 | co_associated_with | gene | 0.40 |
| FCGRT | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ACTB | regulates | gene | 0.60 |
| CLDN5 | activates | gene | 0.60 |
| GAPDH | regulates | gene | 0.60 |
| SDHA | regulates | gene | 0.60 |
| UBC | regulates | gene | 0.60 |
| ZO1 | activates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| APOE, LRP1, LDLR | debate_co_mention | gene | 0.45 |
| AQP4 | debate_co_mention | gene | 0.45 |
| CAV1 | debate_co_mention | gene | 0.45 |
| CLDN5 | debate_co_mention | gene | 0.45 |
| AQP4 | co_associated_with | gene | 0.40 |
| APOE, LRP1, LDLR | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Piezoelectric Nanochannel BBB Disruption | 0.414 | neurodegeneration | Blood-brain barrier transport mechanisms |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.566
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Dolutegravir induces endoplasmic reticulum stress at the blood-brain barrier. [PMID:39985305] | Huang C, Qu QR, Hoque MT, Bendayan R | FASEB J | 2025 | 1 |
| Profiling Tight Junction Protein Expression in Brain Vascular Malformations. [PMID:40429705] | Pedrosa L, Mosteiro A, Reyes L, Amaro S, | Int J Mol Sci | 2025 | 1 |
| Autophagy alleviates hypoxia-induced blood-brain barrier injury via regulation o [PMID:33280500] | Yang Z, Lin P, Chen B, Zhang X, Xiao W, | Autophagy | 2021 | 1 |
| ROS-responsive nanogels for brain targeted delivery of icariin in the treatment [PMID:41197818] | ["Li X", "Huang J", "Zhou Y", "Chen X", | International journal of pharm | 2026 | 0 |
| Claudins proteins in brain tumors: expression patterns and therapeutic target. [PMID:41399659] | ["Romanowicz A", "\u0141ukaszewicz-Zaj\u | Biochemia medica | 2026 | 0 |
| Testicular Gap (CX43) and Tight Junction (OCLN, CLDN3, 5 and 11) Components in t [PMID:41594443] | Goericke-Pesch S, Röhrs L, Wallrabenstei | Animals : an open access journ | 2026 | 0 |
| Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-r [PMID:40994007] | ["Cueva Vargas J", "Belforte N", "Vidal- | Molecular therapy : the journa | 2026 | 0 |
| Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078] | ["Ranjitha V", "Kumar A", "Kaalappa P"] | Pharmaceutical research | 2025 | 0 |
| Artemether Improves Aβ [PMID:40493345] | ["Cai J", "Liu Y", "Gong L", "Deng S", " | Molecular neurobiology | 2025 | 0 |
| Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-r [PMID:39975311] | ["Cueva-Vargas J", "Belforte N", "Vidal- | bioRxiv : the preprint server | 2025 | 0 |
| Mesenchymal Stem Cells Restore Endothelial Integrity and Alleviate Emotional Imp [PMID:40244194] | ["Chen A", "Duan Y", "Zhou S", "Du F", " | International journal of molec | 2025 | 0 |
| Claudin-1 impairs blood-brain barrier by downregulating endothelial junctional p [PMID:40018968] | Gowrikumar S, Tarudji A, McDonald BZ, Ba | Tissue barriers | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| Antiretroviral drugs efavirenz, dolutegravir and bictegravir dysregulate blood-b [PMID:36969875] | ["Huang C", "Hoque T", "Bendayan R"] | Frontiers in pharmacology | 2023 | 0 |
| Increased cerebral expressions of MMPs, CLDN5, OCLN, ZO1 and AQPs are associated [PMID:28490769] | Du Y, Xu JT, Jin HN, Zhao R, Zhao D, Du | Scientific reports | 2017 | 0 |
| Anti-inflammatory activity of Barleria lupulina: Identification of active compou [PMID:27660013] | ["Senger D", "Hoang M", "Kim K", "Li C", | Journal of ethnopharmacology | 2016 | 0 |